An image of the Move+ Pro in a man's hands.

Light Therapy for Acute and Chronic Pain: A Deep Dive into Photobiomodulation Research

This article was written by Forrest Smith

Photobiomodulation, commonly known as red-light therapy, has gained significant attention in recent years for its potential to alleviate acute and chronic pain. By reducing inflammation and promoting tissue repair, light therapy offers a non-invasive, drug-free alternative for pain management. This article will explore the science behind light therapy for pain relief and highlight five influential research papers that have shaped our understanding of its effectiveness.

How Light Therapy Works for Pain Relief

Light therapy utilizes specific wavelengths of light, typically in the red and near-infrared spectrum, to stimulate cellular processes within the body. When tissue absorbs light at these wavelengths, it triggers a series of events at the cellular level, leading to reduction in inflammation and pain. The key mechanisms involved in pain relief through light therapy include:

  1. Increased cellular energy production: Light therapy stimulates the mitochondria, the cell's energy-producing structures, to produce more adenosine triphosphate (ATP), which fuels various cellular processes, including tissue repair and regeneration.
  2. Reduced inflammation: Light therapy can decrease the production of pro-inflammatory cytokines, which contribute to inflammation and pain. This reduction in inflammation is crucial for the healing process and pain relief.
  3. Enhanced blood circulation: Light therapy increases blood flow and circulation, providing tissues with more oxygen and nutrients while removing waste products. This improved circulation further supports the healing process and reduces inflammation.

Five Influential Research Papers on Light Therapy and Pain Relief

1. Hamblin MR. Mechanisms and applications of the anti-inflammatory effects of photobiomodulation. AIMS Biophys. 2017;4(3):337-361. doi: 10.3934/biophy.2017.3.337f

In this comprehensive review, Dr. Michael R. Hamblin, a leading expert in the field of photobiomodulation, explores the anti-inflammatory effects of light therapy and its applications in various conditions. The paper provides an in-depth analysis of the molecular mechanisms behind light therapy's ability to reduce inflammation and alleviate pain.

2. Chow RT, Johnson MI, Lopes-Martins RA, Bjordal JM. Efficacy of low-level laser therapy in the management of neck pain: a systematic review and meta-analysis of randomised placebo or active-treatment controlled trials. Lancet. 2009 Dec 5;374(9705):1897-908. doi: 10.1016/S0140-6736(09)61522-1

This systematic review and meta-analysis examined the effectiveness of low-level laser therapy (LLLT), a form of light therapy, in managing neck pain. The authors analyzed 16 randomized controlled trials and concluded that LLLT was more effective than placebo in reducing pain and improving function in individuals with neck pain.

3. DE Oliveira MF, Johnson DS, Demchak T, Tomazoni SS, Leal-Junior EC. Low-intensity LASER and LED (photobiomodulation therapy) for pain control of the most common musculoskeletal conditions. Eur J Phys Rehabil Med. 2022 Apr;58(2):282-289. doi: 10.23736/S1973-9087.21.07236-1

This review covers how photobiomodulation has been used to treat common painful parts of the body. Furthermore, it discusses how improving dosing parameters has lead to better outcomes. Methodology and dosing of different areas are covered and compared.

4. Navarro-Ledesma S, Carroll J, Burton P, Ana GM. Short-Term Effects of Whole-Body Photobiomodulation on Pain, Quality of Life and Psychological Factors in a Population Suffering from Fibromyalgia: A Triple-Blinded Randomised Clinical Trial. Pain Ther. 2023 Feb;12(1):225-239. doi: 10.1007/s40122-022-00450-5

This triple blinded clinical trial investigates whole body photobiomodulation for the treatment of fibromyalgia, which is related to chronic pain. Through the use of 660nm and 850nm LEDs, the researchers are able to see massive improvements in pain, quality of life, and leisurely physical activity compared to the control group. This study was performed with intense rigor and is an example of what the future of PBM investigations should aim for in terms of methodology.

5. de Freitas LF, Hamblin MR. Proposed Mechanisms of Photobiomodulation or Low-Level Light Therapy. IEEE J Sel Top Quantum Electron. 2016 May-Jun;22(3):7000417. doi: 10.1109/JSTQE.2016.2561201

In this review, De Freitas and Hamblin delve into the proposed mechanisms underlying the effectiveness of photobiomodulation in various medical applications, including pain relief. The authors discuss the biological processes activated by low-level light therapy, such as increased ATP production, modulation of reactive oxygen species, and activation of transcription factors, which collectively contribute to reduced inflammation and pain relief.


Photobiomodulation, or light therapy, has shown promise as a non-invasive, drug-free solution for alleviating acute and chronic pain. The research highlighted in this article represents just a small portion of the growing body of evidence demonstrating light therapy's effectiveness in reducing inflammation and promoting tissue repair, ultimately leading to pain relief.

As our understanding of the underlying mechanisms and optimal treatment parameters for light therapy continues to evolve, it is essential to stay informed about the latest research developments. By doing so, healthcare professionals and individuals seeking pain relief can make informed decisions about incorporating light therapy into their treatment plans. With the potential to transform lives and improve pain management, light therapy is undoubtedly a valuable tool in the quest for management of chronic and acute pain.

For more articles covering the science behind RLT, take a look at:

Forrest Smith

Forrest Smith

Job Title: Founder & CEO
Company: Kineon Labs
LinkedIn: @the-forrest-smith
Location: Atlanta, Georgia, United States
Bio: Forrest Smith is the CEO and co-founder at Kineon. He is an entrepreneur, business operator, strategic planner and leader. Forrest is fluent in Mandarin and English. He also speaks conversational Spanish

About Kineon

Bringing the latest advancements in enhanced red light therapy for home use. Our mission is to get you back on your feet and moving pain-free.